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Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4
Far1 is a bifunctional protein that is required to arrest the cell cycle and establish cell polarity during yeast mating. Here we show that SCF(Cdc4) ubiquitylates Far1 in the nucleus, which in turn targets the multi-ubiquitylated protein to 26S proteasomes most likely located at the nuclear envelop...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2000
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305831/ https://ncbi.nlm.nih.gov/pubmed/11080155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.22.6085 |
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