Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4

Far1 is a bifunctional protein that is required to arrest the cell cycle and establish cell polarity during yeast mating. Here we show that SCF(Cdc4) ubiquitylates Far1 in the nucleus, which in turn targets the multi-ubiquitylated protein to 26S proteasomes most likely located at the nuclear envelop...

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Bibliographic Details
Main Authors:	Blondel, Marc, Galan, Jean-Marc, Chi, Yong, Lafourcade, Céline, Longaretti, Céline, Deshaies, Raymond J., Peter, Matthias
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2000
Subjects:	Articles
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC305831/ https://ncbi.nlm.nih.gov/pubmed/11080155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.22.6085
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Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4

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