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Vav-2 controls NFAT-dependent transcription inB- but not T-lymphocytes

We show here that Vav-2 is tyrosine phosphorylated following antigen receptor engagement in both B- and T-cells, but potentiates nuclear factor of activated T cells (NFAT)-dependent transcription only in B cells. Vav-2 function requires the N-terminus, as well as functional Dbl homology and SH2 doma...

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Enregistré dans:
Publié dans:EMBO J
Auteurs principaux: Doody, Gina M., Billadeau, Daniel D., Clayton, Elizabeth, Hutchings, Amanda, Berland, Robert, McAdam, Simon, Leibson, Paul J., Turner, Martin
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2000
Sujets:
Articles
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305817/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11080163/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.22.6173
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