A Rigidifying Salt-Bridge Favors the Activity of Thermophilic Enzyme at High Temperatures at the Expense of Low-Temperature Activity

BACKGROUND: Thermophilic enzymes are often less active than their mesophilic homologues at low temperatures. One hypothesis to explain this observation is that the extra stabilizing interactions increase the rigidity of thermophilic enzymes and hence reduce their activity. Here we employed a thermop...

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Détails bibliographiques
Auteurs principaux: Lam, Sonia Y., Yeung, Rachel C. Y., Yu, Tsz-Ha, Sze, Kong-Hung, Wong, Kam-Bo
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057955/
https://ncbi.nlm.nih.gov/pubmed/21423654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001027
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