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Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23
The molecular chaperone Hsp90 binds and hydrolyses ATP, but how this ATPase activity regulates the interaction of Hsp90 with a polypeptide substrate is not yet understood. Using the glucocorticoid receptor ligand binding domain as a substrate, we show that dissociation of Hsp90 from bound polypeptid...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2000
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305790/ https://ncbi.nlm.nih.gov/pubmed/11060043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.21.5930 |
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