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Mechanisms of STAT Protein Activation by Oncogenic KIT Mutants in Neoplastic Mast Cells
Mutations in the c-kit gene occur in the vast majority of mastocytosis. In adult patients as well as in the cell line derived from mast cell neoplasms, the mutations occur almost exclusively at amino acid 816 within the kinase domain of KIT. Among the downstream effectors of KIT signaling, STAT3 and...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3057865/ https://ncbi.nlm.nih.gov/pubmed/21135090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.182642 |
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