Mechanisms of STAT Protein Activation by Oncogenic KIT Mutants in Neoplastic Mast Cells

Mutations in the c-kit gene occur in the vast majority of mastocytosis. In adult patients as well as in the cell line derived from mast cell neoplasms, the mutations occur almost exclusively at amino acid 816 within the kinase domain of KIT. Among the downstream effectors of KIT signaling, STAT3 and...

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Bibliographic Details
Main Authors: Chaix, Amandine, Lopez, Sophie, Voisset, Edwige, Gros, Laurent, Dubreuil, Patrice, De Sepulveda, Paulo
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057865/
https://ncbi.nlm.nih.gov/pubmed/21135090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.182642
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