Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

The D816V-mutated variant of Kit triggers multiple signaling pathways and is considered essential for malignant transformation in mast cell (MC) neoplasms. We here describe that constitutive activation of the Stat5-PI3K-Akt-cascade controls neoplastic MC development. Retrovirally transduced active S...

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Detalhes bibliográficos
Main Authors: Harir, Noria, Boudot, Cédric, Friedbichler, Katrin, Sonneck, Karoline, Kondo, Rudin, Martin-Lannerée, Séverine, Kenner, Lukas, Kerenyi, Marc, Yahiaoui, Saliha, Gouilleux-Gruart, Valérie, Gondry, Jean, Bénit, Laurence, Dusanter-Fourt, Isabelle, Lassoued, Kaïss, Valent, Peter, Moriggl, Richard, Gouilleux, Fabrice
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532813/
https://ncbi.nlm.nih.gov/pubmed/18579792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-115477
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