Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation

Stat5 transcription factors are essential gene regulators promoting proliferation, survival, and differentiation of all hematopoietic cell types. Mutations or fusions of oncogenic tyrosine kinases often result in constitutive Stat5 activation. We have modeled persistent Stat5 activity by using an on...

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Autori principali: Friedbichler, Katrin, Kerenyi, Marc A., Kovacic, Boris, Li, Geqiang, Hoelbl, Andrea, Yahiaoui, Saliha, Sexl, Veronika, Müllner, Ernst W., Fajmann, Sabine, Cerny-Reiterer, Sabine, Valent, Peter, Beug, Hartmut, Gouilleux, Fabrice, Bunting, Kevin D., Moriggl, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938843/
https://ncbi.nlm.nih.gov/pubmed/20508164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-258913
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