Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITOR

Phosphoinositide-dependent kinase 1 (PDK1) is a critical activator of multiple prosurvival and oncogenic protein kinases and has garnered considerable interest as an oncology drug target. Despite progress characterizing PDK1 as a therapeutic target, pharmacological support is lacking due to the prev...

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Detalhes bibliográficos
Main Authors: Nagashima, Kumiko, Shumway, Stuart D., Sathyanarayanan, Sriram, Chen, Albert H., Dolinski, Brian, Xu, Youyuan, Keilhack, Heike, Nguyen, Thi, Wiznerowicz, Maciej, Li, Lixia, Lutterbach, Bart A., Chi, An, Paweletz, Cloud, Allison, Timothy, Yan, Youwei, Munshi, Sanjeev K., Klippel, Anke, Kraus, Manfred, Bobkova, Ekaterina V., Deshmukh, Sujal, Xu, Zangwei, Mueller, Uwe, Szewczak, Alexander A., Pan, Bo-Sheng, Richon, Victoria, Pollock, Roy, Blume-Jensen, Peter, Northrup, Alan, Andersen, Jannik N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057779/
https://ncbi.nlm.nih.gov/pubmed/21118801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156463
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