The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α /ATF6α complex

Exercise has been shown to be effective for treating obesity and type 2 diabetes. However, the molecular mechanisms for adaptation to exercise training are not fully understood. Endoplasmic reticulum (ER) stress has been linked to metabolic dysfunction. Here we show that the unfolded protein respons...

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Detalhes bibliográficos
Main Authors: Wu, Jun, Ruas, Jorge L., Estall, Jennifer L., Rasbach, Kyle A., Choi, Jang Hyun, Ye, Li, Boström, Pontus, Tyra, Heather M., Crawford, Robert W., Campbell, Kevin P., Rutkowski, D. Thomas, Kaufman, Randal J., Spiegelman, Bruce M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057411/
https://ncbi.nlm.nih.gov/pubmed/21284983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.01.003
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