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Trapping and dissociation of propafenone derivatives in HERG channels

BACKGROUND AND PURPOSE: Human ether-a-go-go related gene (HERG) channel inhibitors may be subdivided into compounds that are trapped in the closed channel conformation and others that dissociate at rest. The structural peculiarities promoting resting state dissociation from HERG channels are current...

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Sonraí Bibleagrafaíochta
Main Authors: Windisch, A, Timin, EN, Schwarz, T, Stork-Riedler, D, Erker, T, Ecker, GF, Hering, S
Formáid: Artigo
Teanga:Inglês
Foilsithe: Blackwell Science Inc 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057292/
https://ncbi.nlm.nih.gov/pubmed/21175572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01159.x
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