State dependent dissociation of HERG channel inhibitors

BACKGROUND AND PURPOSE: Inhibition of HERG channels prolongs the ventricular action potential and the QT interval with the risk of torsade de pointes arrhythmias and sudden cardiac death. Many drugs induce greater inhibition of HERG channels when the cell membrane is depolarized frequently. The depe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Stork, D, Timin, E N, Berjukow, S, Huber, C, Hohaus, A, Auer, M, Hering, S
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2007
Pynciau:
Research Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2189824/
https://ncbi.nlm.nih.gov/pubmed/17592502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707356
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