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Drug trapping in hERG K(+) channels: (not) a matter of drug size?
Inhibition of hERG K(+) channels by structurally diverse drugs prolongs the ventricular action potential and increases the risk of torsade de pointes arrhythmias and sudden cardiac death. The capture of drugs behind closed channel gates, so-called drug trapping, is suggested to harbor an increased p...
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| Pubblicato in: | Medchemcomm |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5292991/ https://ncbi.nlm.nih.gov/pubmed/28337337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5md00443h |
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