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Drug trapping in hERG K(+) channels: (not) a matter of drug size?
Inhibition of hERG K(+) channels by structurally diverse drugs prolongs the ventricular action potential and increases the risk of torsade de pointes arrhythmias and sudden cardiac death. The capture of drugs behind closed channel gates, so-called drug trapping, is suggested to harbor an increased p...
Shranjeno v:
| izdano v: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Royal Society of Chemistry
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5292991/ https://ncbi.nlm.nih.gov/pubmed/28337337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5md00443h |
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