TCRα enhancer activation occurs via a conformational change of a pre-assembled nucleo-protein complex

The TCR α enhancer (Eα) has served as a paradigm for studying how enhancers organize trans-activators into nucleo-protein complexes thought to recruit and synergistically stimulate the transcriptional machinery. Little is known, however, of either the extent or dynamics of Eα occupancy by nuclear fa...

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Hauptverfasser: Spicuglia, Salvatore, Payet, Dominique, Tripathi, Raj Kamal, Rameil, Pascal, Verthuy, Christophe, Imbert, Jean, Ferrier, Pierre, Hempel, William M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2000
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC305700/
https://ncbi.nlm.nih.gov/pubmed/10790370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.9.2034
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