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DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p
Cdc45p assembles at replication origins before initia tion and is required for origin firing in Saccharomyces cerevisiae. A heat-inducible cdc45 degron mutant was constructed that promotes rapid degradation of Cdc45p at the restrictive temperature. Consistent with a role in initiation, loss of Cdc45...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2000
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305696/ https://ncbi.nlm.nih.gov/pubmed/10790374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.9.2082 |
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