Signal Peptides and Trans-membrane Regions are Broadly Immunogenic and have High CD8+ T Cell Epitope Densities: Implications for Vaccine Development

Cell mediated immune response has a major role in controlling the elimination of infectious agents. The rational design of sub-unit peptide vaccines against intracellular pathogens or cancer requires the use of antigenic sequence/s that can induce highly potent, long lasting and antigen-specific res...

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Bibliographic Details
Main Authors: Kovjazin, Riva, Volovitz, Ilan, Daon, Yair, Vider-Shalit, Tal, Azran, Roy, Tsaban, Lea, Carmon, Lior, Louzoun, Yoram
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056897/
https://ncbi.nlm.nih.gov/pubmed/21316766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2011.01.006
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