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Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity
Effective hemostasis relies on the timely formation of α-thrombin via prothrombinase, a Ca(2+)-dependent complex of factors Va and Xa assembled on the activated platelet surface, which cleaves prothrombin at Arg271 and Arg320. Whereas initial cleavage at Arg271 generates the inactive intermediate pr...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056595/ https://ncbi.nlm.nih.gov/pubmed/21131592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-311035 |
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