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Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity

Effective hemostasis relies on the timely formation of α-thrombin via prothrombinase, a Ca(2+)-dependent complex of factors Va and Xa assembled on the activated platelet surface, which cleaves prothrombin at Arg271 and Arg320. Whereas initial cleavage at Arg271 generates the inactive intermediate pr...

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Bibliografische gegevens
Hoofdauteurs: Wood, Jeremy P., Silveira, Jay R., Maille, Nicole M., Haynes, Laura M., Tracy, Paula B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056595/
https://ncbi.nlm.nih.gov/pubmed/21131592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-311035
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