Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

Activation of the adaptive Ire1-XBP1 pathway has been identified in many solid tumors and hematologic malignancies, including multiple myeloma (MM). Here, we report the identification of STF-083010, a novel small-molecule inhibitor of Ire1. STF-083010 inhibited Ire1 endonuclease activity, without af...

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Autors principals: Papandreou, Ioanna, Denko, Nicholas C., Olson, Michael, Van Melckebeke, Heleen, Lust, Sofie, Tam, Arvin, Solow-Cordero, David E., Bouley, Donna M., Offner, Fritz, Niwa, Maho, Koong, Albert C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056474/
https://ncbi.nlm.nih.gov/pubmed/21081713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-303099
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