Rheb1 is Required for mTORC1 and Myelination in Postnatal Brain Development

mTor kinase is involved in cell growth, proliferation, and differentiation. The roles of mTor activators, Rheb1 and Rheb2, have not been established in vivo. Here, we report that Rheb1, but not Rheb2, is critical for embryonic survival and mTORC1 signaling. Embryonic deletion of Rheb1 in neural prog...

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Autors principals: Zou, Jia, Zhou, Liang, Du, Xiao-Xia, Ji, Yifei, Xu, Jia, Tian, Junlong, Jiang, Wanxiang, Zou, Yi, Yu, Shouyang, Gan, Lingxue, Luo, Maowen, Yang, Qiaona, Cui, Yiyuan, Yang, Wanchun, Xia, Xiaoqiang, Chen, Mina, Zhao, Xia, Shen, Ying, Chen, PO Yu, Worley, Paul F., Xiao, Bo
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056331/
https://ncbi.nlm.nih.gov/pubmed/21238928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.11.020
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