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FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

Productive rearrangement of the T–cell receptor (TCR) β gene and signalling through the pre–TCR–CD3 complex are required for survival, proliferation and differentiation of T–cell progenitors (pro–T cells). Here we identify a role for death receptor signalling in early T–cell development using a domi...

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Autori principali: Newton, Kim, Harris, Alan W., Strasser, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC305633/
https://ncbi.nlm.nih.gov/pubmed/10698935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.5.931
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