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Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint
RhoH, an atypical small Rho-family GTPase, critically regulates thymocyte differentiation through the coordinated interaction with Lck and Zap70. Therefore, RhoH deficiency causes defective T cell development, leading to a paucity of mature T cells. Since there has been no gain-of-function study on...
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| Publicado en: | PLoS One |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4482576/ https://ncbi.nlm.nih.gov/pubmed/26114424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131047 |
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