Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint

RhoH, an atypical small Rho-family GTPase, critically regulates thymocyte differentiation through the coordinated interaction with Lck and Zap70. Therefore, RhoH deficiency causes defective T cell development, leading to a paucity of mature T cells. Since there has been no gain-of-function study on...

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Bibliographic Details
Published in:PLoS One
Main Authors: Tamehiro, Norimasa, Oda, Hiroyo, Shirai, Mutsunori, Suzuki, Harumi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482576/
https://ncbi.nlm.nih.gov/pubmed/26114424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131047
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