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FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor
Productive rearrangement of the T–cell receptor (TCR) β gene and signalling through the pre–TCR–CD3 complex are required for survival, proliferation and differentiation of T–cell progenitors (pro–T cells). Here we identify a role for death receptor signalling in early T–cell development using a domi...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2000
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305633/ https://ncbi.nlm.nih.gov/pubmed/10698935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.5.931 |
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