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Life or death: p53-induced apoptosis requires DNA binding cooperativity

The tumor suppressor p53 provides exquisite protection from cancer by balancing cell survival and death in response to stress. Sustained stress or irreparable damage trigger p53's killer functions to permanently eliminate genetically-altered cells as a potential source of cancer. To prevent the...

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Autori principali: Schlereth, Katharina, Charles, Joël P, Bretz, Anne C, Stiewe, Thorsten
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055192/
https://ncbi.nlm.nih.gov/pubmed/20948308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.20.13595
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