Benzoquinone ansamycin 17AAG binds to mitochondrial voltage-dependent anion channel and inhibits cell invasion

Geldanamycin and its derivative 17AAG [17-(Allylamino)-17-demethoxygeldanamycin, telatinib] bind selectively to the Hsp90 chaperone protein and inhibit its function. We discovered that these drugs associate with mitochondria, specifically to the mitochondrial membrane voltage-dependent anion channel...

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Detalhes bibliográficos
Main Authors: Xie, Qian, Wondergem, Robert, Shen, Yuehai, Cavey, Greg, Ke, Jiyuan, Thompson, Ryan, Bradley, Robert, Daugherty-Holtrop, Jennifer, Xu, Yong, Chen, Edwin, Omar, Hanan, Rosen, Neal, Wenkert, David, Xu, H. Eric, Vande Woude, George F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053964/
https://ncbi.nlm.nih.gov/pubmed/21368131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015181108
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