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Insights into the Biosynthesis of the Benzoquinone Ansamycins Geldanamycin and Herbimycin, Obtained by Gene Sequencing and Disruption

Geldanamycin and the closely related herbimycins A, B, and C were the first benzoquinone ansamycins to be extensively studied for their antitumor properties as small-molecule inhibitors of the Hsp90 protein chaperone complex. These compounds are produced by two different Streptomyces hygroscopicus s...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Rascher, Andreas, Hu, Zhihao, Buchanan, Greg O., Reid, Ralph, Hutchinson, C. Richard
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2005
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC1183368/
https://ncbi.nlm.nih.gov/pubmed/16085885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.71.8.4862-4871.2005
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