Age-Dependent Retinal Iron Accumulation and Degeneration in Hepcidin Knockout Mice

PURPOSE. Iron dysregulation can cause retinal disease, yet retinal iron regulatory mechanisms are incompletely understood. The peptide hormone hepcidin (Hepc) limits iron uptake from the intestine by triggering degradation of the iron transporter ferroportin (Fpn). Given that Hepc is expressed in th...

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Main Authors: Hadziahmetovic, Majda, Song, Ying, Ponnuru, Padmavathi, Iacovelli, Jared, Hunter, Allan, Haddad, Nadine, Beard, John, Connor, James R., Vaulont, Sophie, Dunaief, Joshua L.
Format: Artigo
Language:Inglês
Published: Association for Research in Vision and Ophthalmology, Inc. 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053271/
https://ncbi.nlm.nih.gov/pubmed/20811044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-6113
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