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Efficient In Vivo Doxycycline and Cre Recombinase–Mediated Inducible Transgene Activation in the Murine Trabecular Meshwork

PURPOSE. To generate new mouse lines that facilitate inducible gene activation in the murine trabecular meshwork in vivo. METHODS. Two expression cassettes were knocked into the 3′-UTR of the Myocilin (Myoc) locus, an abundantly expressed extracellular matrix protein produced by cells of the trabecu...

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Bibliografski detalji
Glavni autori: Liu, Pu, Fu, Xueyao, Johnson, Randy L.
Format: Artigo
Jezik:Inglês
Izdano: Association for Research in Vision and Ophthalmology, Inc. 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053115/
https://ncbi.nlm.nih.gov/pubmed/21051732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-5052
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