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Efficient In Vivo Doxycycline and Cre Recombinase–Mediated Inducible Transgene Activation in the Murine Trabecular Meshwork
PURPOSE. To generate new mouse lines that facilitate inducible gene activation in the murine trabecular meshwork in vivo. METHODS. Two expression cassettes were knocked into the 3′-UTR of the Myocilin (Myoc) locus, an abundantly expressed extracellular matrix protein produced by cells of the trabecu...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Association for Research in Vision and Ophthalmology, Inc.
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3053115/ https://ncbi.nlm.nih.gov/pubmed/21051732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-5052 |
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