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Efficient In Vivo Doxycycline and Cre Recombinase–Mediated Inducible Transgene Activation in the Murine Trabecular Meshwork

PURPOSE. To generate new mouse lines that facilitate inducible gene activation in the murine trabecular meshwork in vivo. METHODS. Two expression cassettes were knocked into the 3′-UTR of the Myocilin (Myoc) locus, an abundantly expressed extracellular matrix protein produced by cells of the trabecu...

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Библиографические подробности
Главные авторы: Liu, Pu, Fu, Xueyao, Johnson, Randy L.
Формат: Artigo
Язык:Inglês
Опубликовано: Association for Research in Vision and Ophthalmology, Inc. 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053115/
https://ncbi.nlm.nih.gov/pubmed/21051732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-5052
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