Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork

PURPOSE: To determine if proteasome inhibition using MG132 increased the efficiency of FIV vector–mediated transduction in human trabecular meshwork (TM)-1 cells and monkey organ-cultured anterior segments (MOCAS). METHODS: TM-1 cells were pretreated for 1 hour with 0.5% dimethyl sulfoxide (DMSO; ve...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Aktas, Zeynep, Rao, Hongyu, Slauson, Sarah R., Gabelt, B'Ann T., Larsen, Inna V., Sheridan, Rachael T. C., Herrnberger, Leonie, Tamm, Ernst R., Kaufman, Paul L., Brandt, Curtis R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2018
Témata:
Glaucoma
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961099/
https://ncbi.nlm.nih.gov/pubmed/29340644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22074
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