The Kinase Inhibitory Region of SOCS-1 is Sufficient to Inhibit T-helper 17 and other Immune Functions in Experimental Allergic Encephalomyelitis

Suppressors of cytokine signaling (SOCS) negatively regulate the immune response, primarily by interfering with the JAK/STAT pathway. We have developed a small peptide corresponding to the kinase inhibitory region (KIR) sequence of SOCS-1, SOCS1-KIR, which inhibits kinase activity by binding to the...

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Hlavní autoři: Jager, Lindsey D., Dabelic, Rea, Waiboci, Lilian W., Lau, Kenneth, Haider, Mohammad S., Ahmed, Chulbul M. I., Larkin, Joseph, David, Samuel, Johnson, Howard M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053067/
https://ncbi.nlm.nih.gov/pubmed/21131060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2010.10.018
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