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Clozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT(7) receptors: radioligand binding and functional evidence for GPCR homodimer protomer interactions
RATIONALE: The h5-HT(7) receptor is subject to inactivation by risperidone and 9-OH-risperidone, apparently through a pseudo-irreversible complex formed between these drugs and the receptor. Although risperidone and 9-OH-risperidone (“inactivating antagonists”) completely inactivate the receptor, on...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3052287/ https://ncbi.nlm.nih.gov/pubmed/20827463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-010-2001-x |
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