Comparison of the molecular interactions of two antagonists, MEN16132 or icatibant, at the human kinin B(2) receptor

BACKGROUND AND PURPOSE: Icatibant is a well-known kinin B(2) receptor antagonist currently used for angiooedema attacks. MEN16132 is a non-peptide B(2) receptor antagonist, more potent and long lasting than icatibant in different models. Here we studied the reasons for these differences between the...

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Autori principali: Meini, S, Bellucci, F, Catalani, C, Cucchi, P, Giolitti, A, Giuliani, S, Quartara, L, Rotondaro, L, Zappitelli, S, Maggi, CA
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2011
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3051391/
https://ncbi.nlm.nih.gov/pubmed/21108627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01133.x
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