A different molecular interaction of bradykinin and the synthetic agonist FR190997 with the human B(2) receptor: evidence from mutational analysis

1. Binding affinity at the [(3)H]-BK binding site and activity as inositol phosphate (IP) production by the peptide bradykinin (BK) and the nonpeptide FR190997 were studied at wild-type or point-mutated human B(2) receptors (hB(2)R) expressed in CHO cells. 2. The effect of the following mutations we...

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Autors principals: Bellucci, Francesca, Meini, Stefania, Cucchi, Paola, Catalani, Claudio, Reichert, Wolfgang, Zappitelli, Sabrina, Rotondaro, Luigi, Quartara, Laura, Giolitti, Alessandro, Maggi, Carlo Alberto
Format: Artigo
Idioma:Inglês
Publicat: 2003
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Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574048/
https://ncbi.nlm.nih.gov/pubmed/12970081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705454
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