Negative cooperativity in binding of muscarinic receptor agonists and GDP as a measure of agonist efficacy

BACKGROUND AND PURPOSE: Conventional determination of agonist efficacy at G-protein coupled receptors is measured by stimulation of guanosine-5′-γ−thiotriphosphate (GTPγS) binding. We analysed the role of guanosine diphosphate (GDP) in the process of activation of the M(2) muscarinic acetylcholine r...

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Bibliografiske detaljer
Main Authors: Jakubík, J, Janíčková, H, El-Fakahany, EE, Doležal, V
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2011
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3051377/
https://ncbi.nlm.nih.gov/pubmed/20958290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01081.x
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