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Complexin Clamps Asynchronous Release by Blocking a Secondary Ca(2+)-Sensor via its Accessory α-Helix
Complexin activates and clamps neurotransmitter release; impairing complexin function decreases synchronous, but increases spontaneous and asynchronous synaptic vesicle exocytosis. Here, we show that complexin – different from the Ca(2+)-sensor synaptotagmin-1 – activates synchronous exocytosis by p...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050570/ https://ncbi.nlm.nih.gov/pubmed/21145004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.11.001 |
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