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Evidence of the E*-E equilibrium from rapid kinetics of Na(+) binding to activated protein C and factor Xa*
Na(+) binding to thrombin enhances the procoagulant and prothrombotic functions of the enzyme and obeys a mechanism that produces two kinetic phases: one fast (in the μs time scale) due to Na(+) binding to the low activity form E to produce the high activity form E:Na(+), and another considerably sl...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050025/ https://ncbi.nlm.nih.gov/pubmed/20809655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp105502c |
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