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Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
Gain-of-function mutations in leucine-rich repeat kinase 2 (LRRK2) cause familial as well as sporadic Parkinson’s disease (PD) characterized by age-dependent dopaminergic neuron (DN) degeneration1, 2. The molecular mechanism of LRRK2 action is not known. Here we show that LRRK2 interacts with the mi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049892/ https://ncbi.nlm.nih.gov/pubmed/20671708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09191 |
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