Alkaline Phosphatase Knock-Out Mice Recapitulate the Metabolic and Skeletal Defects of Infantile Hypophosphatasia

Hypophosphatasia is an inborn error of metabolism characterized by deficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP) and skeletal disease due to impaired mineralization of cartilage and bone matrix. We investigated two independently generated TNSALP gene knock-o...

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Main Authors: FEDDE, KENTON N., BLAIR, LIBBY, SILVERSTEIN, JULIE, COBURN, STEPHEN P., RYAN, LAWRENCE M., WEINSTEIN, ROBERT S., WAYMIRE, KATRINA, NARISAWA, SONOKO, MILLÁN, JOSÉ L., MACGREGOR, GRANT R., WHYTE, MICHAEL P.
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049802/
https://ncbi.nlm.nih.gov/pubmed/10620060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/jbmr.1999.14.12.2015
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