PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

BACKGROUND: PG545 is a heparan sulfate (HS) mimetic that inhibits tumour angiogenesis by sequestering angiogenic growth factors in the extracellular matrix (ECM), thus limiting subsequent binding to receptors. Importantly, PG545 also inhibits heparanase, the only endoglycosidase which cleaves HS cha...

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Bibliographic Details
Main Authors: Dredge, K, Hammond, E, Handley, P, Gonda, T J, Smith, M T, Vincent, C, Brandt, R, Ferro, V, Bytheway, I
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
Subjects:
Translational Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049593/
https://ncbi.nlm.nih.gov/pubmed/21285983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.11
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