PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

BACKGROUND: PG545 is a heparan sulfate (HS) mimetic that inhibits tumour angiogenesis by sequestering angiogenic growth factors in the extracellular matrix (ECM), thus limiting subsequent binding to receptors. Importantly, PG545 also inhibits heparanase, the only endoglycosidase which cleaves HS cha...

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Detaylı Bibliyografya
Asıl Yazarlar: Dredge, K, Hammond, E, Handley, P, Gonda, T J, Smith, M T, Vincent, C, Brandt, R, Ferro, V, Bytheway, I
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2011
Konular:
Translational Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049593/
https://ncbi.nlm.nih.gov/pubmed/21285983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.11
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