PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

BACKGROUND: PG545 is a heparan sulfate (HS) mimetic that inhibits tumour angiogenesis by sequestering angiogenic growth factors in the extracellular matrix (ECM), thus limiting subsequent binding to receptors. Importantly, PG545 also inhibits heparanase, the only endoglycosidase which cleaves HS cha...

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Autori principali: Dredge, K, Hammond, E, Handley, P, Gonda, T J, Smith, M T, Vincent, C, Brandt, R, Ferro, V, Bytheway, I
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049593/
https://ncbi.nlm.nih.gov/pubmed/21285983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.11
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