The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-κB

BACKGROUND: Despite therapeutic advances, the prognosis of patients with metastatic soft tissue sarcoma (STS) remains extremely poor. The results of a recent clinical phase II study, evaluating the protective effects of the semisynthetic flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside (monoHER) on doxo...

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Detalhes bibliográficos
Main Authors: Jacobs, H, Bast, A, Peters, G J, van der Vijgh, W J F, Haenen, G R M M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049564/
https://ncbi.nlm.nih.gov/pubmed/21245867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6606065
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