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A comparative study between catalase gene therapy and the cardioprotector monohydroxyethylrutoside (MonoHER) in protecting against doxorubicin-induced cardiotoxicity in vitro

Cardiotoxicity is the main dose-limiting side effect of doxorubicin in the clinic. Being a free radical producer, doxorubicin affects the heart specifically because of its low antioxidant capacity. Among those antioxidants, catalase is present in very low levels in the heart compared to other organs...

詳細記述

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書誌詳細
主要な著者: Abou El Hassan, M A I, Rabelink, M J W E, van der Vijgh, W J F, Bast, A, Hoeben, R C
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376857/
https://ncbi.nlm.nih.gov/pubmed/14647150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601430
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