Inducible SUMO modification of TANK alleviates its repression of TLR7 signalling

Adaptor proteins allow temporal and spatial coordination of signalling. In this study, we show SUMOylation of the adaptor protein TANK and its interacting kinase TANK-binding kinase 1 (TBK1). Modification of TANK by the small ubiquitin-related modifier (SUMO) at the evolutionarily conserved Lys 282...

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Bibliografske podrobnosti
Main Authors: Renner, Florian, Saul, Vera V, Pagenstecher, Axel, Wittwer, Tobias, Schmitz, Michael Lienhard
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
Teme:
Scientific Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049432/
https://ncbi.nlm.nih.gov/pubmed/21212807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.207
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