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Repression of Smad4 transcriptional activity by SUMO modification.
Smad4 plays a key role in TGF-beta (transforming growth factor beta)/Smad-mediated transcriptional responses. We show that Smad4 is sumoylated both in vivo and in vitro. Recent studies showed that sumoylation of Smad4 regulated its stability, but the effect of sumoylation on the intrinsic transcript...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224064/ https://ncbi.nlm.nih.gov/pubmed/14750902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031867 |
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