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Repression of Smad4 transcriptional activity by SUMO modification.

Smad4 plays a key role in TGF-beta (transforming growth factor beta)/Smad-mediated transcriptional responses. We show that Smad4 is sumoylated both in vivo and in vitro. Recent studies showed that sumoylation of Smad4 regulated its stability, but the effect of sumoylation on the intrinsic transcript...

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Bibliografske podrobnosti
Main Authors: Long, Jianyin, Wang, Guannan, He, Dongming, Liu, Fang
Format: Artigo
Jezik:Inglês
Izdano: 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224064/
https://ncbi.nlm.nih.gov/pubmed/14750902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031867
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