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Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells

HSCs either self-renew or differentiate to give rise to multipotent cells whose progeny provide blood cell precursors. However, surprisingly little is known about the factors that regulate this choice of self-renewal versus differentiation. One candidate is the Notch signaling pathway, with ex vivo...

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Detalhes bibliográficos
Main Authors: Varnum-Finney, Barbara, Halasz, Lia M., Sun, Mingyi, Gridley, Thomas, Radtke, Freddy, Bernstein, Irwin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049401/
https://ncbi.nlm.nih.gov/pubmed/21285514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43868
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