Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells

Bone marrow endothelial cells (ECs) are essential for reconstitution of hematopoiesis, but their role in self-renewal of long term-hematopoietic stem cells (LT-HSCs) is unknown. We have developed angiogenic models to demonstrate that EC-derived angiocrine growth factors support in vitro self-renewal...

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Auteurs principaux: Butler, Jason M., Nolan, Daniel J., L.Vertes, Eva, Varnum-Finney, Barbara, Kobayashi, Hideki, Hooper, Andrea T., Seandel, Marco, Shido, Koji, White, Ian A., Kobayashi, Mariko, Witte, Larry, May, Chad, Shawber, Carrie, Kimura, Yuki, Kitajewski, Jan, Rosenwaks, Zev, Bernstein, Irwin D., Rafii, Shahin
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866527/
https://ncbi.nlm.nih.gov/pubmed/20207228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.02.001
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