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Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus
Notch signaling establishes boundaries in the thymus by inducing T-cell commitment and inhibiting a B-cell choice. Here, we show a significant 1.6-fold increased generation of B-cell precursors in thymuses from mice deficient for Notch target Hes5 compared with wild-type littermates. We further show...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2254545/ https://ncbi.nlm.nih.gov/pubmed/18048645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-079855 |
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