Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus

Notch signaling establishes boundaries in the thymus by inducing T-cell commitment and inhibiting a B-cell choice. Here, we show a significant 1.6-fold increased generation of B-cell precursors in thymuses from mice deficient for Notch target Hes5 compared with wild-type littermates. We further show...

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Bibliographic Details
Main Authors: Varnum-Finney, Barbara, Dallas, Mari H., Kato, Keizo, Bernstein, Irwin D.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254545/
https://ncbi.nlm.nih.gov/pubmed/18048645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-079855
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